Inflammatory Bowel Disease
The precise aetiology of inflammatory bowel disease unknown, but evidence suggests that the normal intestinal flora trigger an abnormal immune reaction in patients with a multifactorial genetic predisposition. No specific environmental, dietary, or infectious causes have been identified.
Crohn disease is a chronic transmural inflammatory bowel disease that usually affects the distal ileum and colon but may occur in any part of the GI tract. Symptoms include diarrhoea and abdominal pain. Abscesses, internal and external fistulas, and bowel obstruction may arise. Extra intestinal symptoms, particularly arthritis, may occur. Diagnosis is by colonoscopy and imaging studies. Treatment is pharmaceutical, and often surgery.